Caryophyllene Oxide CAS 1139-30-6 Food Grade Additive for Flavors

Caryophyllene oxide (CAS 1139-30-6) is a natural sesquiterpene oxide for Toothpaste, mouthwash, baking, candy, and beverages

Caryophyllene Oxide has a sweet, woody aroma and is mainly found in lemon balm and geranium. It is the product of the oxidation of Caryophyllene.

Occurrence and Sources:
Caryophyllene oxide is a natural component of essential oils, including those from black caraway, cloves, hops, basil, oregano, black pepper, lavender, rosemary, and more. 
It is formed when caryophyllene oxidizes. 

Caryophyllene oxide (CAS 1139-30-6) is a natural sesquiterpene oxide for Toothpaste, mouthwash, baking, candy, and beverages

Key Properties and Effects:
Anticancer: Caryophyllene oxide can potentiate apoptosis induced by other agents and suppress tumor cell invasion. It can also inhibit key pathways involved in cancer development, such as the MAPK and PI3K/AKT/mTOR/S6K1 pathways. 
Analgesic: Caryophyllene oxide can enhance the pain-relieving effects of other drugs like parac. It is also known to have analgesic and anti-inflammatory activity. 
Anti-inflammatory: Studies suggest that caryophyllene oxide can reduce inflammation and support the immune system. 
Antimicrobial: It has been studied for its potential antifungal activity. 
Aroma: Caryophyllene oxide has a sweet, woody, and carrot-like odor. 

Caryophyllene oxide (CAS 1139-30-6) is a natural sesquiterpene oxide for Toothpaste, mouthwash, baking, candy, and beverages

Caryophyllene oxide main uses are as follows:

Fragrances and daily chemicals:
• Perfumery: Used as a woody-spicy modifier, commonly found in lavender, amber, and woody perfumes.
• Cosmetics: The addition amount is usually 0.05–20 ppm (finished product) or 0.01–5 wt-% (semi-finished product), which can give a lasting woody aroma and a mild and refreshing feeling.
• Oral care: Toothpaste, mouthwash, etc. use its antibacterial and fragrance properties.
Food flavoring: It can be used as a natural food flavor for baking, candy, and beverages to provide a warm and spicy background flavor.

Medicine and health care:
• Analgesia and anti-inflammatory: Animal experiments show that it has a significant inhibitory effect on acetic acid-induced pain.
• Antifungal: Used in in vitro models to treat fungal infections such as onychomycosis.
• Antioxidant: DPPH method IC₅₀≈5.4 mg/mL, can be developed as a natural antioxidant.
• Reagents for calcium channel blockade and myocardial protection research.

Agriculture:
• Repellent: Repellent activity against brown planthoppers>75% (100 μg/cm²).

Caryophyllene oxide (CAS 1139-30-6) is a natural sesquiterpene oxide for Toothpaste, mouthwash, baking, candy, and beverages

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Caryophyllene oxide (CAS 1139-30-6) is a natural sesquiterpene oxide for Toothpaste, mouthwash, baking, candy, and beverages